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Observe Carefully (1)pentobarbital will minimize the extent or effect of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to your minimize in fentanyl plasma concentrations, lack of efficacy or, possibly, improvement of the wi